Day 1 :
Nevada Center for Biomedical Research, USA
Time : 10:00-11:00
Kenny L De Meirleir is an Emeritus Professor in Physiology, Pathophysiology and Medicine. He has examined, diagnosed and treated almost 20,000 ME/CFS patients in all 5 continents of the world. Currently his scientific and medical practices are situated in Belgium at Himmunitas and the Nevada Center for Biomedical Research at the University of Nevada (USA).
The goal of our study was to assemble a panel of immune and inflammatory markers, which would accurately identify chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) cases. Four markers were initially investigated to establish differences between CFS/ME 140 cases and 140 controls. Serum interleukin 8 (IL-8), soluble CD14 (sCD14, a surrogate marker for bacterial lipopolysaccharides (LPS)), and prostaglandin E2 (PGE2) were measured for all subjects as were absolute CD57+ lymphocytes. Median values for all analyzed parameters were established; independent sample t-test, Mann-Whitney test and ROC curve analysis were used to investigate difference linked to gender and age. ROC statistics revealed a significant difference between CFS/ME cases and controls (p<0.001) for all parameters separately, both in the male and female cohorts. Both sensitivity and specificity were high. Logistic regression analysis for the combination of parameters was correctly predicted in 89% of male CFS/ME cases and in 97% of female CFS/ME cases. This panel differentiates CFS/ME cases from controls with high sensitivity and specificity and therefore represents a potential tool in selecting CFS/ME subjects for clinical studies. Each of these four biological markers relate strongly to the disorder. PGE2 activates dendritic cells and suppresses their ability to attract T cells. PGE2 additionally promotes Th2, Th17 and Tregs and also modulates chemokine production (e.g. IL-8). Our data suggest that LPS, likely from gut bacteria, plays an important role in the pathophysiology of CFS/ME. Subsequent markers will be required to subcategorize CFS/ME subjects in order to tailor therapeutic solutions.
University Hospital Ibn Rochd, Morocco
Time : 11:20-12:20
Fatima Zahra Alaoui is the Professor of internal medicine , University Hospital Ibn Rochd, Casablanca, Morocco. Fatima Zahra Alaoui has her speciality in Internal Medicine, Inflammatory Diseases, Auto Immune Disease and Uveitis, Head of department of medicine 2014-2017.
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that primarily affects joints, it may result in deformed and painful joints which can lead to loss of function and RA affects between 0.5 and 1% of population. In Morocco, RA is the most frequent inflammatory rheumatism and affects young women, most commonly with high predominance of early erosions, which provoke deformities in a great number of patients with systemic features as rheumatoid nodules, amyloidosis and vasculitis are rare in our series. The aim of this study is to analyze clinical, epidemiological and evolutive features of RA in Morocco for a period of 33 years. 1400 cases of RA were observed in a period between 1981 and 2014. All patients fulfilled the ACR criteria 1987 and the new criteria of RA 2010; among 1400 cases of RA, female predominance was noted with sex ratio F/M=5/1. The mean age was 34.5 (25–54). All patients had hand and wrist involvement with respect to distal interphalangeal joints. DAS 28 (disease activity score) was 6.78 (5.6–8.5). Deformities were present in 75% of cases and sedimentation rate was increased around: 78 mm. C-reactive protein (CRP) » 24 mg/l. Rheumatoid factor was positive in 58% of patients. Anti-cyclic citrullinated peptide (CCP) antibodies: (from 2009) were positive in 28% of cases; RA in Morocco is severe because of high predominance of structural destruction and deformities. It occurs in young people in comparison with literature.