Eva M. Carmona Porquera
Dr. Carmona is a physician-scientist focused on understanding the role of chronic inflammation triggered by infectious antigens in the development of interstitial lung diseases (ILD). Her research to date has focused on understanding the immunomodulatory effects of fungal beta-glucans (BG) in innate immune cells. Particularly; she had characterized the role of BG on dendritic cells and their participation in T-cell polarization (Th1 and Th17). Currently, her group is interested in determining the mechanisms by which BG and other infectious antigens modulate B-lymphocyte activation and how activated B-lymphocytes may drive the development of inflammation and fibrosis in a subset of patients with ILD. Her group has recently shown that BG activated B-lymphocytes release a pro-inflammatory cytokine profile that participates in neutrophil recruitment potentially contributing to lung epithelial damage. They have also identified the NLRP3 inflammasome of circulating human B-lymphocytes as a key component in innate and adaptive immune response in response to fungal and bacterial antigens. More recently, they are investigating the role of antifibrotic drugs in B-cells activation.
Immunology, B-cells biology and interstitial lung diseases.